ORGANIC ANION–TRANSPORTING POLYPEPTIDES - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 78

TABLE 5.1. Genetic and Protein Characteristics of Human OATPs

mRNA

Gene Protein

Reference Splice

Name Chromosome Size (kb) Exons Accession Size (bp) Variants Name Previous Names Size (aa)

SLCO1A2 12p12 126 17 NM 021094 2919 yes OATP1A2 OATP, OATP-A 670

SLCO1B1 12p12 109 14 NM 006446 2830 OATP1B1 OATP2, LST-1, OATP-C 691

SLCO1B3 12p12 101 13 NM 019844 2646 OATP1B3 OATP8 702

SLCO1C1 12p12 58 18 NM 017435 3381 yes OATP1C1 OATP-F 712

SLCO2A1 3q21 97 14 NM 005630 4040 yes OATP2A1 hPGT 643

SLCO2B1 11q13 55 16 NM 007256 4108 yes OATP2B1 OATP-B 709

SLCO3A1 15q26 310 16 NM 013272 2740 yes OATP3A1 OATP-D 710

SLCO4A1 20q13.1 30 16 NM 016354 2796 yes OATP4A1 OATP-E 722

SLCO4C1 5q21 63 13 NM 180991 5334 OATP4C1 OATP-H 724

SLCO5A1 8q13.1 163 10 NM 030958 3692 OATP5A1 OATP-J 848

SLCO6A1 5q21 127 14 NM 173488 2515 OATP6A1 OATP-I, GST 719