Biomedical Engineering Reference
In-Depth Information
ORGANIC ANION-TRANSPORTING
POLYPEPTIDES
ROMMEL G. TIRONA AND RICHARD B. KIM
University of Western Ontario, London, Ontario, Canada
5.1. Overview of the OATP Superfamily
5.1.1. Introduction
5.1.2. Nomenclature
5.2. Molecular Characteristics of OATPs
5.2.1. Gene Structure
5.2.2. Protein Structure
5.2.3. Transport Mechanisms
5.3. Expression and Regulation of OATPs
5.3.1. Tissue Distribution
5.3.2. Postranslational Regulation
5.3.3. Transcriptional Regulation
5.4. OATP Substrates and Inhibitors
5.4.1. Substrates
5.4.2. Substrate Specificity of OATPs
5.4.3. Inhibitors
5.5. Pharmacology and Physiology of OATPs
5.5.1. Clinical Pharmacology
5.5.2. Physiological and Pathophysiological Roles
5.6. Conclusions
References
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