CLINICAL RELEVANCE: DRUG–DRUG INTERACTION,PHARMACOKINETICS,PHARMACODYNAMICS, AND TOXICITY - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 799

TABLE 24.2. ( Continued )

Inhibitor/ Measured Putative

Drug Inducer Effect/Toxicity Mechanism Refs.

Statins Cyclosporin A Increased plasma AUC

and maximum
plasma
concentration

Inhibition of
OATPs, CYP3A4,
CYP2C8,
CYP2C9

631

Pravastatin Cyclosporin A Increased AUC and

plasma levels

Inhibition of OATPs 643

Cerivastatin Cyclosporin A Increased AUC and

plasma levels

Inhibition of OATPs,
CYP2C8/3A4

632,633

Atorvastatin Cyclosporin A Increased AUC and

plasma levels

Inhibition of
OATPs, CYP3A4

636

Pitavastatin Cyclosporin A Increased AUC and

plasma levels

Inhibition of OATPs 745

645,647

Statins Gemfibrozil Increased myotoxicity Inhibition of

OATPs, MRP2,
BCRP, CYP2C8,
CYP2C9

Simvastatin Gemfibrozil Increased AUC and

plasma levels

Inhibition of OATPs 637

Cerivastatin Gemfibrozil Increased AUC and

plasma levels

Inhibition of OATPs,
CYP2C8/3A4

638,644,
645

Lovastatin Gemfibrozil Increased AUC and

plasma levels

Inhibition of OATPs 641

Rosuvastatin Gemfibrozil Increased AUC and

plasma levels

Inhibition of
OATPs, CYP2C9

640

Metformin Cimetidine Decreased renal

clearance, increased
AUC

Inhibition of OCTs,
OATs, OATPs

690

Procainamide Cimetidine Decreased renal

clearance, increased
AUC

Inhibition of OCTs,
OATs, OATPs

689,720,
721,
746

Dofetilide Cimetidine Decreased renal

clearance, increased
AUC

Inhibition of OCTs,
OATs, OATPs

721,747

Pilsicainide Cimetidine Decreased renal

clearance, increased
AUC and half life

Inhibition of OCTs,
OATs, OATPs

692

Levofloxacin Cimetidine Decreased renal

clearance, increased
AUC

Inhibition of OCTs,
OATs, OATPs

721

Pilsicainide Cetirizime Mutually reduction of

renal clearance

Inhibition of OCTs,
MDR1

691