Biomedical Engineering Reference
In-Depth Information
24
CLINICAL RELEVANCE:
DRUG-DRUG INTERACTION,
PHARMACOKINETICS,
PHARMACODYNAMICS, AND
TOXICITY
SERENA MARCHETTI
Netherlands Cancer Institute, Amsterdam, The Netherlands; and University of Florence,
Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
ROBERTO MAZZANTI
University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
JOS H. BEIJNEN AND JAN H. M. SCHELLENS
Netherlands Cancer Institute, Amsterdam, The Netherlands; and Utrecht University,
Utrecht, The Netherlands
24.1. Introduction
24.2. Interactions Mediated by ABC Drug Transporters
24.2.1. ABCB1 (MDR1, P-Glycoprotein)
24.2.2. ABCG2 (BCRP)
24.2.3. ABCC Family (Multidrug Resistance-Associated Proteins, MRP1 to MRP9)
24.3. Interactions Mediated by Organic Anion and Cation Transporters
24.3.1. Organic Anion Transporters
24.3.2. Organic Anion-Transporting Polypeptides
24.3.3. Organic Cation Transporters
24.3.4. Organic Cation/Carnitine Transporters
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