INTERPLAY OF DRUG TRANSPORTERS AND ENZYMES ON HEPATIC DRUG PROCESSING - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 730

D g 3 R

100

100

Dg3 R

Dg2 total

Dg2 total

10

10

Dg3 bile Dg3 bile

1

1

0.1

0.1

0 100 200 300 400 500

0 100 200 300 400 500

Time (min)

Time (min)

(b)

(a)

100 100

Dg 3 R

Dg 3 R

Dg2 total

Dg2 total

10 10

Dg3 bile

Dg3 bile

1 1

0.1 0.1

0 100 200 300 400 500 0 100 200 300 400 500

Time (min) Time (min)

(c) (d)

FIGURE 23.12. Simulation of the effect of doubling the CL influx ( a ), CL efflux ( b ), CL int , met ( c ), and CL int , sec