Biomedical Engineering Reference
In-Depth Information
100
E
nalapril
R
100
100
100
Enalapril
R
Enalaprilat
total
Enalaprilat
total
80
80
10
10
60
60
40
40
1
1
20
20
Enalapril
Bil
e
Enala
p
ril
Bile
0
0.1
0
0.1
0
100
200
300
400
0
100
200
300
400
Time (min)
Time (min)
(a)
(b)
100
100
100
En
alapril
R
100
En
alapril
R
Enalaprilat
total
80
Enalaprilat
total
80
10
10
60
60
40
40
1
1
20
Enalapril
Bile
20
Enalapril
B
il
e
0.1
0
0.1
0
0
100
200
300
400
0
100
200
300
400
Time (min)
Time (min)
(d)
(c)
FIGURE 23.7.
Simulations of enalapril based on the ZPBPK model. The CL
influx
(
a
), CL
efflux
(
b
), CL
int
,
met
(
c
)or
CL
int
,
sec
(
d
) were altered from 100% (solid line) to 200% (short dashed line) and 50% (dashed-dotted-dotted line); all
other parameters were kept constant in the simulation to examine the decay of enalapril in reservoir (enalapril
R
), and
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