INTERPLAY OF DRUG TRANSPORTERS AND ENZYMES ON HEPATIC DRUG PROCESSING - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 717

TABLE 23.1. Solved Equations on the Biliary Excretion Clearance, Hepatic Metabolic Clearance, and Total Hepatic Clearance
Solutions for the Simple PBPK Model a

Clearance Term CL influx and CL efflux are comparable to Q ,CL int , met , and CL int , sec CL influx = CL efflux Q ,CL int , met , and CL int , sec

Qf u CL influx CL int , sec
Q (CL efflux + CL int , met + CL int , sec ) +

Q ; f u CL int , sec

CL liver , ex

f u CL influx (CL int , sec + CL int , met ) Q + f u (CL int , sec + CL int , met )

Qf u CL influx CL int , met
Q (CL efflux + CL int , met + CL int , sec ) +

Q ; f u CL int , met

CL liver , met

f u CL influx (CL int , sec + CL int , met ) Q + f u (CL int , sec + CL int , met )

Qf u CL influx (CL int , sec + CL int , met )
Q (CL efflux + CL int , met + CL int , sec ) +

Q ; f u (CL int , sec + CL int , met )
Q +

CL liver , tot

f u CL influx (CL int , sec + CL int , met ) f u (CL int , sec + CL int , met )

Source : Ref. 85; with permission.
a These equations are reduced in complexity when CL influx = CL efflux Q L ,CL int , met and CL int , sec . Q is the plasma flow rate to the liver.