DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 701

71. Ohnishi A, Matsuo H, Yamada S, Takanaga H, Morimoto S, Shoyama Y, Ohtani H,
Sawada Y. 2000. Effect of furanocoumarin derivatives in grapefruit juice on the uptake of
vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4. Br J Pharmacol
130(6):1369-1377.
72. Spahn-Langguth H, Langguth P. 2001. Grapefruit juice enhances intestinal absorption of
the P-glycoprotein substrate talinolol. Eur J Pharm Sci 12(4):361-367.
73. Tian R, Koyabu N, Takanaga H, Matsuo H, Ohtani H, Sawada Y. 2002. Effects of grapefruit
juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharm Res
19(6):802-809.
74. Xu J, Go ML, Lim LY. 2003. Modulation of digoxin transport across Caco-2 cell mono-
layers by citrus fruit juices: lime, lemon, grapefruit, and pummelo. Pharm Res 20(2):169-
176.
75. Honda Y, Ushigome F, Koyabu N, Morimoto S, Shoyama Y, Uchiumi T, Kuwano
M, Ohtani H, Sawada Y. 2004. Effects of grapefruit juice and orange juice compo-
nents on P-glycoprotein- and MRP2-mediated drug efflux. Br J Pharmacol 143(7):856-
864.
76. Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. 1999. Grape-
fruit juice activates P-glycoprotein-mediated drug transport. Pharm Res 16(4):478-485.
77. Lim SL, Lim LY. 2006. Effects of citrus fruit juices on cytotoxicity and drug transport
pathways of Caco-2 cell monolayers. Int J Pharm 307(1):42-50.
78. Eagling VA, Profit L, Back DJ. 1999. Inhibition of the CYP3A4-mediated metabolism
and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by
grapefruit juice components. Br J Clin Pharmacol 48(4):543-552.
79. Takanaga H, Ohnishi A, Matsuo H, Sawada Y. 1998. Inhibition of vinblastine efflux
mediated by P-glycoprotein by grapefruit juice components in Caco-2 cells. Biol Pharm
Bull 21(10):1062-1066.
80. Romiti N, Tramonti G, Donati A, Chieli E. 2004. Effects of grapefruit juice on the
multidrug transporter P-glycoprotein in the human proximal tubular cell line HK-2. Life
Sci 76(3):293-302.
81. Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y.
2005. Citrus juices inhibit the function of human organic anion-transporting polypeptide
OATP-B. Drug Metab Dispos 33(4):518-523.
82. Yee GC, Stanley DL, Pessa LJ, Dalla Costa T, Beltz SE, Ruiz J, Lowenthal DT. 1995.
Effect of grapefruit juice on blood cyclosporin concentration. Lancet 345(8955):955-
956.
83. Ducharme MP, Warbasse LH, Edwards DJ. 1995. Disposition of intravenous and oral
cyclosporine after administration with grapefruit juice. Clin Pharmacol Ther 57(5):485-
491.
84. Edwards DJ, Fitzsimmons ME, Schuetz EG, Yasuda K, Ducharme MP, Warbasse LH,
Woster PM, Schuetz JD, Watkins P. 1999. 6 ,7 -Dihydroxybergamottin in grapefruit juice
and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and
P-glycoprotein. Clin Pharmacol Ther 65(3):237-244.
85. Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown
MB, Guo W, Rossi SJ, Benet LZ, Watkins PB. 1997. Role of intestinal P-glycoprotein
(mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol
Ther 62(3):248-260.