ORGANIC ANION TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 53

TABLE 4.1. OAT Family Members

Original Human Human

Gene Name Name and Prototypical Transport Tissue Membrane Species Gender Gene

(Gene symbol) a Reference Substrate(s) Mechanism b Distribution Localization Identified Difference Locus

OAT1/NKT
(SLC22A6)

NKT; ref. 2 p -Aminohippurate OA-DC

exchange

Kidney, brain, eyes Basolateral Human, mouse, rat,

pig, flounder

(rat) male >
female

11q12.3

OAT2/NLT
(SLC22A7)

NLT; ref. 3 p -Aminohippurate unknown Kidney, liver unknown Human, mouse, rat (mouse liver)

female >
male

6q21.1-2

OAT3/Roct
(SLC22A8)

Roct; ref. 4 Estrone 3-sulfate OA-DC

exchange

Kidney, brain, eyes,
liver, adrenal
glands

Basolateral Human, mouse, rat,

pig, rabbit

(rat) male >
female

11q12.3

OAT4
(SLC22A11)

Ref. 14 Estrone 3-sulfate OA-DC

exchange

Kidney, placenta,
mouse brain and
mouse testis

Apical Human unknown 11q13.1

OAT5
(SLC22A19)

Ref. 84 Ochratoxin A unknown Kidney unknown Mouse, rat unknown 11q12.3

OAT6
(SLC22A20)

Ref. 75 Estrone 3-sulfate unknown Mouse olfactory

mucosa

unknown Mouse unknown unknown

URAT1/RST
(SLC22A12)

RST; ref. 85 Urate Urate-anion

exchange

Kidney Apical Human, mouse (mouse)

male >
female

11q13.1

a SLC, solute carrier family.
b OA, organic anion; DC, dicarboxylate.