DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 695

TABLE 22.6. Interactions of Flavonoids with OATPs
Cell Line

Effect on

Flavonoid Used Substrates OATPs Refs.

Flavones
Apigenin HeLa/OATP-C DHEAS ↓ Uptake 36

Chrysin HeLa/OATP-C DHEAS ↔ Uptake 36

Luteolin HeLa/OATP-C DHEAS ↓ Uptake 36

Diosmetin HeLa/OATP-C DHEAS ↓ Uptake 36

Diosmin HeLa/OATP-C DHEAS ↔ Uptake 36

Flavonols
Fisetin

HeLa/OATP-C DHEAS ↓ Uptake 36

↔

Galangin HeLa/OATP-C DHEAS Uptake 36

↔

Kaempferol HeLa/OATP-C DHEAS Uptake 36

Morin HeLa/OATP-C DHEAS ↓ Uptake 36

Myricetin HeLa/OATP-C DHEAS ↓ Uptake 36

Quercetin HeLa/OATP-C DHEAS ↔ Uptake 36

Rutin HeLa/OATP-C

HEK/OATP-B

DHEAS
Estrone
3-sulfate

↑ Uptake
↓ Uptake

36
110

Flavanones
Hesperitin HeLa/OATP-C DHEAS ↓ Uptake 36

Hesperidin HeLa/OATP-C DHEAS ↓ Uptake 36

Naringenin HeLa/OATP-C DHEAS ↓ Uptake 36

Naringin HeLa/OATP-C DHEAS ↓ Uptake 36

Flavanols
Catechin HEK/OATP-B Estrone

3-sulfate

↓ Uptake 110

Epicatechin HEK/OATP-B Estrone

3-sulfate

↓ Uptake 110

EGC HeLa/OATP-C

HEK/OATP-B

DHEAS
Estrone
3-sulfate

↔ Uptake 36

110

↓ Uptake

ECG HEK/OATP-B Estrone

3-sulfate

↓ Uptake 110

↓ Uptake
↓

EGCG HeLa/OATP-C

HEK/OATP-B

DHEAS
Estrone
3-sulfate

36
110 Uptake

Flavanolols
Silibinin/
silymarin

HeLa/OATP-C DHEAS ↓ Uptake 36

Isoflavones
Biochanin A HeLa/OATP-C DHEAS ↓ Uptake 36

Genistein HeLa/OATP-C DHEAS ↓ Uptake 36

Genistin HeLa/OATP-C DHEAS ↔ Uptake 36

Daidzein HeLa/OATP-C DHEAS ↔ Uptake 36

Daidzin HeLa/OATP-C DHEAS ↔ Uptake 36