DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 682

TABLE 22.3. ( Continued )
Flavonoid Cell Line Used Substrates Effect on Pgp Refs.

Naringenin KB-C2 carinoma cells

MCF-7 breast cancer cells

Daunorubicin
Daunomycin

↔ Activity
↓ Activity
↔ Activity
↓

152
178
177
149 MBEC4 endothelial cells Vincristine Activity

Naringin MCF-7 breast cancer cells

MBEC4 endothelial cells

Daunomycin
Vincristine

↔ Activity 177

149

↔ Activity

Flavanols
Catechin CH R C5 cells Rhodamine 123 ↔ Activity 104

CG CH R C5 cells Rhodamine 123 ↓ Activity 104

Epicatechin KB-C2 carinoma cells Rhodamine 123

Daunorubicin
Rhodamine 123

↔ Activity
↔ Activity
↔ Activity

179

CH R C5 cells 104

ECG KB-C2 carinoma cells Rhodamine 123

Daunorubicin
Rhodamine 123

↓ Activity
↓ Activity
↓ Activity

179

CH R C5 cells 104

EGC KB-C2 carinoma cells Rhodamine 123

Daunorubicin

↓ Activity
↓ Activity

179