ORGANIC CATION/CARNITINE TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 48

32. Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N, Nikaido H, Sai Y, Koizumi
A, Shoji Y et al. 1999. Primary systemic carnitine deficiency is caused by mutations
in a gene encoding sodium ion-dependent carnitine transporter. Nat Genet 21:91-
94.
33. Kobayashi D, Irokawa M, Maeda T, Tsuji A, Tamai I. 2005. Carnitine/organic cation
transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal
epithelial cells. Reproduction 130:931-937.
34. Kai S, Yakushiji K, Yamauchi M, Ito C, Kuwajima M, Osada Y, Toshimori K. 2005.
Expression of novel organic cation/carnitine transporter (OCTN2) in the mouse pancreas.
Tissue Cell 37:309-315.
35. Duran JM, Peral MJ, Calonge ML, Ilundain AA. 2005. OCTN3: A Na + -independent
L-carnitine transporter in enterocytes basolateral membrane. J Cell Physiol 202:929-
935.
36. Lamhonwah AM, Ackerley CA, Tilups A, Edwards VD, Wanders RJ, Tein I. 2005.
OCTN3 is a mammalian peroxisomal membrane carnitine transporter. Biochem Biophys
Res Commun 338:1966-1972.
37. Enomoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N, Goto A, Sakamoto
A, Niwa T, Kanai Y, Anders MW, Endou H. 2002. Molecular identification of a novel
carnitine transporter specific to human testis. Insights into the mechanism of carnitine
recognition. J Biol Chem 277:36262-36271.
38. Gong S, Lu X, Xu Y, Swiderski CF, Jordan CT, Moscow JA. 2002. Identification of OCT6
as a novel organic cation transporter preferentially expressed in hematopoietic cells and
leukemias. Exp Hematol 30:1162-1169.
39. Kwok B, Yamauchi A, Rajesan R, Chan L, Dhillon U, Gao W, Xu H, Wang B, Takahashi
S, Semple J, et al. 2006. Carnitine/xenobiotics transporters in the human mammary gland
epithelia, MCF12A. Am J Physiol Regul Integr Comp Physiol 290:R793-802.
40. Nakanishi T, Hatanaka T, Huang W, Prasad PD, Leibach FH, Ganapathy ME, Ganapathy
V. 2001. Na + - and Cl − -coupled active transport of carnitine by the amino acid transporter
ATB(0, + ) from mouse colon expressed in HRPE cells and Xenopus oocytes. J Physiol
532:297-304.
41. Ganapathy ME, Ganapathy V. 2005. Amino Acid Transporter ATB0, + as a delivery system
for drugs and prodrugs. Curr Drug Targets Immune Endocrinol Metab Disord 5:357-364.
42. Taylor PM. 2001. Absorbing competition for carnitine. J Physiol 532:283.
43. Berezowski V, Miecz D, Marszalek M, Broer A, Broer S, Cecchelli R, Nalecz KA. 2004.
Involvement of OCTN2 and B0, + in the transport of carnitine through an in vitro model
of the blood-brain barrier. J Neurochem 91:860-1872.
44. Tein I. 2003. Carnitine transport: pathophysiology and metabolism of known molecular
defects. J Inherit Metab Dis 26:147-169.
45. Lahjouji K, Elimrani I, Wu J, Mitchell GA, Qureshi IA. 2002. A heterozygote phenotype
is present in the jvs +/ − mutant mouse livers. Mol Genet Metab 76:76-80.
46. Yokogawa K, Yonekawa M, Tamai I, Ohashi R, Tatsumi Y, Higashi Y, Nomura M,
Hashimoto N, Nikaido H, Hayakawa J, et al. 1999. Loss of wild-type carrier-mediated
L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice. Hepatology
30:997-1001.
47. Brass EP. 2002. Pivalate-generating prodrugs and carnitine homeostasis in man. Pharmacol
Rev 54:589-598.