POLYMORPHISMS OF DRUG TRANSPORTERS AND CLINICAL RELEVANCE - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 635

24 healthy volunteers Digoxin PK, Pgp duodenal

expression

3435T genotype associated
with ↑ AUC(0-4 h) and
C max than 3435C

125

50 healthy Caucasian
subjects

Digoxin PK No statistical association 126

metaanalysis Digoxin AUC, C max ,

baseline intestinal
MDR1 and Pgp
expression

No statistical association 127

14 healthy subjects Cyclosporine PK No statistical association 129

44 Caucasian patients Chemotherapy response,

MDR1 expression, Pgp
expression, Pgp activity
in lymphoblast cells

No statistical association 188

113 Caucasian children Occurrence and outcome of

ALL

TT associated with occurrence
of ALL; CC associated with
↓ probability of event-free
survival and overall survival

189

102 children Etoposide PK CC associated with ↑ day 29

CL

190

53 patients MDR1 lymphoblast

expression; overall
survival

No statistical association 191

123 patients Plasma antiretroviral

concentration, change in
CD4 cell count

3435TT > CT > CC ↑ in CD4
cells; 3435TT < CT < CC
median plasma drug
concentration

136