ORGANIC CATION/CARNITINE TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 46

REFERENCES
1. Lahjouji K, Mitchell GA, Qureshi IA. 2001. Carnitine transport by organic cation trans-
porters and systemic carnitine deficiency. Mol Genet Metab 73:287-297.
2. McCloud E, Ma TY, Grant KE, Mathis RK, Said HM. 1996. Uptake of L-carnitine by a
human intestinal epithelial cell line, Caco-2. Gastroenterology 111:1534-1540.
3. Elimrani I, Lahjouji K, Seidman E, Roy MJ, Mitchell GA, Qureshi I. 2003. Expression and
localization of organic cation/carnitine transporter OCTN2 in Caco-2 cells. Am J Physiol
Gastrointest Liver Physiol 284:G863-G871.
4. Lahjouji K, Malo C, Mitchell GA, Qureshi IA. 2002. L-Carnitine transport in mouse renal
and intestinal brush-border and basolateral membrane vesicles. Biochim Biophys Acta
1558:82-93.
5. Koepsell H, Schmitt BM, Gorboulev V. 2003. Organic cation transporters. Rev Physiol
Biochem Pharmacol 150:36-90.
6. Koepsell H, Endou H. 2004. The SLC22 drug transporter family. Pflugers Arch 447:666-
676.
7. Rioux JD, Daly MJ, Silverberg MS, Lindblad K, Steinhart H, Cohen Z, Delmonte T, Kocher
K, Miller K, Guschwan S, et al. 2001. Genetic variation in the 5q31 cytokine gene cluster
confers susceptibility to Crohn disease. Nat Genet 29:223-228.
8. Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M, Tsuji A. 1997. Cloning and
characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS
Lett 419:107-111.
9. Tamai I, Ohashi R, Nezu JI, Sai Y, Kobayashi D, Oku A, Shimane M, Tsuji A. 2000.
Molecular and functional characterization of organic cation/carnitine transporter family in
mice. J Biol Chem 275:40064-40072.
10. Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V. 2000.
Structural and functional characteristics and tissue distribution pattern of rat OCTN1,
an organic cation transporter, cloned from placenta. Biochim Biophys Acta 1466:315-
327.
11. Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A. 1999. Novel
membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent
transport of organic cations. J Pharmacol Exp Ther 289:768-773.
12. Alnouti Y, Petrick JS, Klaassen CD. 2006. Tissue distribution and ontogeny of organic
cation transporters in mice. Drug Metab Dispos 34:477-482.
13. Xuan W, Lamhonwah AM, Librach C, Jarvi K, Tein I. 2003. Characterization of or-
ganic cation/carnitine transporter family in human sperm. Biochem Biophys Res Commun
306:121-128.
14. Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y, Tsuji A. 1998.
Molecular and functional identification of sodium ion-dependent, high affinity human
carnitine transporter OCTN2. J Biol Chem 73:20378-20382.
15. Tamai I, China K, Sai Y, Kobayashi D, Nezu J, Kawahara E, Tsuji A. 2001. Na( + )-coupled
transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular
localization in kidney. Biochim Biophys Acta 1512:273-284.
16. Wagner CA, L ukewille U, Kaltenbach S, Moschen I, Broer A, Risler T, Broer S, Lang
F. 2000. Functional and pharmacological characterization of human Na( + )-carnitine co-
transporter hOCTN2. Am J Physiol Renal Physiol 279:F584-F591.