POLYMORPHISMS OF DRUG TRANSPORTERS AND CLINICAL RELEVANCE - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 619

21

POLYMORPHISMS OF DRUG
TRANSPORTERS AND CLINICAL
RELEVANCE

LESLIE W. CHINN, JASON M. GOW, AND DEANNA L. KROETZ
University of California-San Francisco, San Francisco, California

21.1. Genetic Variation and Drug Response
21.2. Genetic Variation in Membrane Transporters
21.3. Functional Analysis of Transporter Variants
21.3.1. SLC Transporters
21.3.2. ABC Transporters
21.4. Clinical Significance of Drug Transporter Variants
21.4.1. SLC Transporters
21.4.2. ABC Transporters
21.5. Conclusions
References

21.1. GENETIC VARIATION AND DRUG RESPONSE

Numerous environmental and genetic factors influence interindividual variation in
drug response. Differences in age, disease state, alcohol and recreational drug use,
concomitant drug and natural-product administration, and organ function are all as-
sociated with variability in specific drug responses. 1 Pharmacogenetics is the study
of the contribution of genetic variability in drug response genes to variability in