AGE- AND GENDER-RELATED DIFFERENCES IN XENOBIOTIC TRANSPORTER EXPRESSION - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 612

gender-specific differences in mRNA expression in mice. The implication of these
observations is that age- and gender-related differences in pharmacokinetics may be
ascribed in part to differences in transporter expression. Therefore, when attempt-
ing to explain age- or gender-related discrepancies in xenobiotic pharmacokinetics,
functional studies of transporters that display variations in expression should be con-
sidered to exclude or confirm a contribution of transporter expression patterns to the
differences observed in pharmacokinetics.
Acknowledgments
The authors wish to acknowledge present and previous predoctoral and postdoctoral
follows of this laboratory for their laboratory work in obtaining much of the data in
the chapter and for making suggestions for its improvement.
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