IN VITRO–IN VIVO SCALE-UP OF DRUG TRANSPORT ACTIVITIES - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 564

(a)
(b)
(c)
FIGURE 19.2. Schematic diagram of the method for estimating the contribution of each
transporter to the overall hepatic uptake: ( a ) using reference compounds; ( b ) using the relative
expression levels estimated from Western blot analysis; ( c ) using transporter-specific inhibitors.
The details are described in the text. ( See insert for color representation of figure .)