IN VITRO–IN VIVO SCALE-UP OF DRUG TRANSPORT ACTIVITIES - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 557

19

IN VITRO-IN VIVO SCALE-UP OF
DRUG TRANSPORT ACTIVITIES

KAZUYA MAEDA AND YUICHI SUGIYAMA
University of Tokyo, Tokyo, Japan

19.1. Introduction
19.2. Theoretical Background for the Prediction of In Vivo Pharmacokinetics from
In Vitro Data
19.2.1. Contribution of Each Transporter to Overall Membrane Transport
19.2.2. Rate-Determining Process in Apparent Intrinsic Organ Clearance
19.2.3. Relationship Between Apparent Intrinsic Organ Clearance and Organ
Clearance
19.3. Prediction of Hepatic Transport from In Vitro Data
19.4. Prediction of Renal Transport from In Vitro Data
19.5. Prediction of Blood-Brain Barrier and Blood-CSF Barrier Transport from
In Vitro Data
19.6. Prediction of Intestinal Transport from In Vitro Data
19.7. Prediction of Drug-Drug Interactions from In Vitro Data
19.8. Conclusions
References