Biomedical Engineering Reference
In-Depth Information
profiles, low and erratic oral bioavailability still prevents many promising drug candi-
dates from entering clinical trials. It has been demonstrated that drug transporters in
the intestinal tract may play a critical role in the absorption and disposition of some
drugs. However, they may also mediate significant drug-drug interactions. Recogni-
tion of the importance of intestinal transporters will certainly help the development
of drugs with optimal absorption properties and benefit the design of individualized
dosing regimens.
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