DRUG TRANSPORTERS IN THE INTESTINE - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 495

16

DRUG TRANSPORTERS
IN THE INTESTINE

YAMING SU AND PATRICK J. SINKO
Rutgers, the State University of New Jersey, Piscataway, New Jersey

16.1. Introduction
16.2. Intestinal Permeation of Drugs
16.2.1. Transcellular Diffusion
16.2.2. Paracellular Transport
16.2.3. Transcytosis
16.3. Drug Transporters in the Small Intestine
16.4. Impact of Small Intestinal Transporters on Oral Absorption of Drugs
16.4.1. PepT1-Mediated Absorptive Transport
16.4.2. OATP-Mediated Absorptive Transport
16.4.3. Pgp-Mediated Secretory Transport
16.4.4. BCRP-Mediated Secretory Transport
16.4.5. Transporters Localized on the Basolateral Membrane of Enterocytes
16.5. Functional Modulation of Intestinal Transporters to Optimize Oral Absorption of
Drugs
16.6. Conclusions
References