ORGANIC CATION TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 31

43. Urakami Y, Okuda M, Masuda S, Saito H, Inui KI. 1998. Functional characteristics and
membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2,
mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther 287(2):800-805.
44. Karbach U, Kricke J, Meyer-Wentrup F, Gorboulev V, Volk C, Loffing-Cueni D, Kaissling
B, Bachmann S, Koepsell H. 2000. Localization of organic cation transporters OCT1 and
OCT2 in rat kidney. Am J Physiol Renal Physiol 279(4):F679-F687.
45. Sugawara-Yokoo M, Urakami Y, Koyama H, Fujikura K, Masuda S, Saito H, Naruse T,
Inui K, Takata K. 2000. Differential localization of organic cation transporters rOCT1 and
rOCT2 in the basolateral membrane of rat kidney proximal tubules. Histochem Cell Biol
114(3):175-180.
46. Sweet DH, Miller DS, Pritchard JB. 2000. Basolateral localization of organic cation trans-
porter 2 in intact renal proximal tubules. Am J Physiol Renal Physiol 279(5):F826-F834.
47. Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, Ogawa O,
Inui K. 2002. Gene expression levels and immunolocalization of organic ion transporters
in the human kidney. J Am Soc Nephrol 13(4):866-874.
48. Dudley AJ, Bleasby K, Brown CD. 2000. The organic cation transporter OCT2 mediates the
uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1)
cell monolayers. Br J Pharmacol 131(1):71-79.
49. Lee W, Kim RB. 2004. Transporters and renal drug elimination. Annu Rev Pharmacol
Toxicol 44:137-166.
50. Masuda S, Terada T, Yonezawa A, Tanihara Y, Kishimoto K, Katsura T, Ogawa O, Inui
K. 2006. Identification and functional characterization of a new human kidney-specific
H + /organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc
Nephrol 17(8):2127-2135.
51. Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, Moriyama Y. 2005. A human
transporter protein that mediates the final excretion step for toxic organic cations. Proc
Natl Acad SciUSA102(50):17923-17928.
52. Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji
A. 2001. Molecular and physiological evidence for multifunctionality of carnitine/organic
cation transporter OCTN2. Mol Pharmacol 59(2):358-366.
53. Meyer-Wentrup F, Karbach U, Gorboulev V, Arndt P, Koepsell H. 1998. Membrane lo-
calization of the electrogenic cation transporter rOCT1 in rat liver. Biochem Biophys Res
Commun 248(3):673-678.
54. Ciarimboli G, Schlatter E. 2005. Regulation of organic cation transport. Pflugers Arch
449(5):423-441.
55. Mehrens T, Lelleck S, Cetinkaya I, Knollmann M, Hohage H, Gorboulev V, Boknik P,
Koepsell H, Schlatter E. 2000. The affinity of the organic cation transporter rOCT1 is
increased by protein kinase C-dependent phosphorylation. J Am Soc Nephrol 11(7):1216-
1224.
56. Ciarimboli G, Struwe K, Arndt P, Gorboulev V, Koepsell H, Schlatter E, Hirsch JR. 2004.
Regulation of the human organic cation transporter hOCT1. J Cell Physiol 201(3):420-428.
57. Pietig G, Mehrens T, Hirsch JR, Cetinkaya I, Piechota H, Schlatter E. 2001. Properties and
regulation of organic cation transport in freshly isolated human proximal tubules. J Biol
Chem 276(36):33741-33746.
58. Cetinkaya I, Ciarimboli G, Yalcinkaya G, Mehrens T, Velic A, Hirsch JR, Gorboulev V,
Koepsell H, Schlatter E. 2003. Regulation of human organic cation transporter hOCT2 by