DRUG TRANSPORT IN THE KIDNEY - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 466

TABLE 15.1. Drug Transporters Expressed in the Kidneys
Gene Name Protein Name Tissue Distribution Predominant Substrate a Refs.

SLC15: Proton Oligopeptide Cotransporter Family
SLC15A1 PEPT1 Intestine, kidney Di- and tripeptides, -lactam antibiotics, valaciclovir, bestatin 70,71

SLC15A2 PEPT2 Kidney, lung, brain Di- and tripeptides, -lactam antibiotics, valaciclovir, bestatin 70,71

SLC17: Vesicular Glutamate Transporter Family
SLC17A1 NPT1 Kidney, liver Organic acids, phosphate, chloride 67

SLC21/SLC0: Organic Anion-Transporting Polypepetide Family
Slco1a1 Oatp1 Brain, colon, kidney,

liver, lung, intestine

BSP, TC, E 2 17 G, LTC 4 , DNP-SG, T3, T4, aldosterone,
cortisol, ouabain, OTA, temocaprirat

15,58

SLCO1A2 OATP1A2 Brain Bile salt, PGE 2 , fexofenadine 15,60

Slco1a3 Oat-k1 Kidney TC, E 2 17 G, ES, DHEAS, folate, T3, T4, MTX 15,61

Slco1a3 Oat-k2 Kidney TC, E 2 17 G, ES, DHEAS, folate, T3, T4, MTX 15,62

Slco1a7 Oatp3 Kidney, lung, retina TC, T3, T4 15,63

SLCO2A1 PGT Ubiquitous Eicosanoids, PGs, thromboxane B2, E 2 17 G 15,60

SLCO2B1 OATP-B Brain, liver, kidney, heart,

placenta

ES, DHEAS, PGE 2 ,E 2 17 G, BSP 15,60

SLCO3A1 OATP-D Ubiquitous ES, PGE 2 , benzylpenicillin 15,60

SLCO4A1 OATP-E Ubiquitous TC, T3, T4, rT3, PGE 2 , benzylpenicillin 15,60

SLCO4C1 OATP-H Kidney T3, digoxin, ouabain 61

Slco1a6 Oatp5 Kidney Unknown 15,64

SLC22: Organic Cation-Anion Transporter Family
SLC22A1

OCT1 Liver TEA, NMN, choline, MPP, dopamine 88,89

SLC22A2 OCT2 Kidney TEA, NMN, choline, MPP, dopamine 87,93

SLC22A3 OCT3 Liver, skeletal muscle TEA, guanidine, histamine 95,96