DRUG TRANSPORT IN THE KIDNEY - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 463

15

DRUG TRANSPORT IN THE KIDNEY

NAOHIKO ANZAI AND HITOSHI ENDOU
Kyorin University School of Medicine, Shinkawa, Mitaka-shi, Tokyo, Japan

15.1. Introduction
15.2. Molecular Identification of Renal Drug Transporters
15.2.1. Organic Anion Transporters
15.2.2. Organic Cation Transporters
15.3. Regulation of Renal Drug Transporters
15.3.1. Gender and Developmental Differences
15.3.2. Phosphorylation
15.3.3. Protein-Protein Interaction
15.3.4. Glycosylation
15.4. Renal Handling of Selected Drugs
15.4.1. Cephalosporin Antibiotics
15.4.2. Diuretics
15.4.3. Nonsteroidal Anti-Inflammatory Drugs
15.4.4. Antiviral Drugs
15.5. Miscellaneous Aspects of Renal Drug Transporters
15.5.1. Transporter-Mediated Drug-Drug Interactions
15.5.2. Transporter-Mediated Nephrotoxicity
15.5.3. In Vitro and In Vivo Model Systems to Study Renal Drug Transport
15.6. Conclusions
References