Biomedical Engineering Reference
In-Depth Information
provided crucial information regarding the importance of these transporters to xeno-
biotic and endobiotic disposition in vivo. The existence of genetic variants of OCTs
with altered function in cellular assays suggests that genetic variation in OCTs may
contribute to interindividual variability in drug disposition or drug response; further
study of the importance of these variants to human drug disposition may soon allow
for clinical pharmacogenetic testing and improvements in rational drug therapy.
Acknowledgments
This work was supported by National Institutes of Health grants GM36780 and
GM61390.
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