Biomedical Engineering Reference
In-Depth Information
murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile
and to liver disease. Cell 75:451-462.
46. Ueda K, Cardarelli C, Gottesman MM, Pastan I. 1987. Expression of a full-length cDNA
for the human “MDR1” gene confers resistance to colchicine, doxorubicin, and vinblas-
tine. Proc Natl Acad SciUSA84:3004-3008.
47. Sun J, He ZG, Cheng G, Wang SJ, Hao XH, Zou MJ. 2004. Multidrug resistance P-
glycoprotein: crucial significance in drug disposition and interaction. Med Sci Monit
10:RA5-RA14.
48. Demeule M, Regina A, Jodoin J, Laplante A, Dagenais C, Berthelet F, Moghrabi A,
Beliveau R. 2002. Drug transport to the brain: key roles for the efflux pump P-glycoprotein
in the blood-brain barrier. Vascul Pharmacol 38:339-348.
49. Cisternino S, Rousselle C, Debray M, Scherrmann JM. 2004. In situ transport of vin-
blastine and selected P-glycoprotein substrates: implications for drug-drug interactions
at the mouse blood-brain barrier. Pharm Res 21:1382-1389.
50. Ronaldson PT, Lee G, Dallas S, Bendayan R. 2004. Involvement of P-glycoprotein in the
transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia
cell lines. Pharm Res 21:811-818.
51. Tahara H, Kusuhara H, Fuse E, Sugiyama Y. 2005. P-glycoprotein plays a major role
in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a
limited role in its biliary excretion. Drug Metab Dispos 33:963-968.
52. Hsiao P, Sasongko L, Link JM, Mankoff DA, Muzi M, Collier AC, Unadkat JD. 2006.
Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a
concentration inhibition analysis, and comparison with human data. J Pharmacol Exp
Ther 317:704-710.
53. Ohashi R, Kamikozawa Y, Sugiura M, Fukuda H, Yabuuchi H, Tamai I. 2006. Effect
of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent
bepotastine besilate. Drug Metab Dispos 34:793-799.
54. Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR. 1998. The
drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease
inhibitors. J Clin Invest 101:289-294.
55. Washington CB, Wiltshire HR, Man M, Moy T, Harris SR, Worth E, Weigl P, Liang
Z, Hall D, Marriott L, Blaschke TF. 2000. The disposition of saquinavir in normal and
P-glycoprotein deficient mice, rats, and in cultured cells. Drug Metab Dispos 28:1058-
1062.
56. Rao VV, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC, Piwnica-
Worms D. 1999. Choroid plexus epithelial expression of MDR1 P glycoprotein and
multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid-drug
permeability barrier. Proc Natl Acad SciUSA96:3900-3905.
57. Beaulieu E, Demeule M, Ghitescu L, Beliveau R. 1997. P-Glycoprotein is strongly
expressed in the luminal membranes of the endothelium of blood vessels in the brain.
Biochem J 326(Pt 2):539-544.
58. Drion N, Risede P, Cholet N, Chanez C, Scherrmann JM. 1997. Role of P-170
glycoprotein in colchicine brain uptake. J Neurosci Res 49:80-88.
59. Virgintino D, Robertson D, Errede M, Benagiano V, Girolamo F, Maiorano E, Roncali L,
Bertossi M. 2002. Expression of P-glycoprotein in human cerebral cortex microvessels.
J Histochem Cytochem 50:1671-1676.
 
Search WWH ::




Custom Search