DRUG TRANSPORT IN THE LIVER - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 365

TABLE 13.2. Human Hepatic Efflux Transport Proteins
Protein/

Gene

Trivial Names Symbol Substrates/References

MRP1
MRP, GS-X

ABCC1 Daunorubicin; doxorubicin; etoposide; vincristine [233],

Glutathione [38], Methotrexate (MTX) [124]

MRP3
MOAT-D
MLP2
cMOAT2

ABCC3 Acetaminophen glucuronide [69], E 2 17G; monovalent and

sulfated bile salts; MTX [34], Etoposide [38]

MRP4
MOAT-B

ABCC4 Azidothymidine [234], cAMP; cGMP; adefovir

[235,236,309], MTX [310], Prostaglandin E 1 ;
prostaglandin E 2 [235]

ABCC5 cAMP; cGMP [236], Adefovir [235]

MRP5
MOAT-C
ABC11

MRP6
MOAT-E
MLP1

ABCC6 BQ-123 [307]

BSEP
Sister Pgp

ABCB11 Conjugated and unconjugated bile acids; TC; Pravastatin

[237, 314]

MRP2
CMOAT
cMRP

ABCC2 Acetaminophen glucuronide; carboxydichlorofluorescein

[238], Camptothecin; doxorubicin [239], Cerivastatin;
estrone 3-sulfate [240], Cisplatin; vincristine [241],
Etoposide [242], Glibenclamide; indomethacin; rifampin
[243], Glucuronide, glutathione, and sulfate conjugates;
LT C 4 [30], MTX [244], Pravastatin [99]

MDR1
Pgp

ABCB1 Amprenavir; indinavir; nelfinavir; ritonavir; saquinavir

[311,312], Aldosterone; corticosterone; dexamethasone;
digoxin [245], Cyclosporin A; MX [246], Debrisoquine;
erythromycin; lovastatin; terfenadine [139], Digoxin;
quinidine [313], Doxorubicin; paclitaxel; rhodamine 123
[247,248], Etoposide [249], Fexofenadine [139],
Levofloxacin; grepafloxacin [250], Losartan; vinblastine
[251], Tacrolimus [252], Talinolol [253], Verapamil;
norverapamil [254]

MDR3
PFIC3
Phospholipid
flippase
MDR2/3

ABCB4 Phospholipids [23]

BCRP
MXR, ABCP

ABCG2 Daunorubicin; doxorubicin; MX; sulfated conjugates

glucuronides [21], Topotecan; Irinotecan [32], Prazosin;
rhodamine 123 [255], Testosterone; tamoxifen; estradiol
[256]