BREAST CANCER RESISTANCE PROTEIN - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 339

Suvannasankha
et al. 159

ALL RT-PCR FC:

BXP-21,
BXP-34,
5D3,
mitoxantrone
transport

30 pretreatment blast
samples

BXP-21, BXP-34, and 5D3 and positivity in 43, 37, and 47%
of cases, respectively. Function in 70% of cases. No
correlation between gene expression or protein expression
and function. BXP-21 staining predictive of PFS. No aa482
mutations.

Benderra et al. 156 AML RT-PCR 149 de novo samples ABCG2 expression predictive of complete remission, 4-year

DFS, and 4-year overall survival. Predictive in patients
receiving daunorubicin and mitoxantrone but not idarubicin.

Uggla et al. 157 AML RT-PCR 40 AML samples No difference in ABCG2 expression between responders and

nonresponders. In responders, higher expression was
related to shorter overall survival.

a IHC, immunohistochemistry; FC, flow cytometry.