Biomedical Engineering Reference
In-Depth Information
12
BREAST CANCER RESISTANCE
PROTEIN
ROBERT W. ROBEY, ORSOLYA POLGAR, JOHN DEEKEN,
KENNETH K. W. TO, AND SUSAN E. BATES
National Cancer Institute, Bethesda, Maryland
12.1. Introduction
12.2. Genetics of ABCG2
12.3. Protein Structure and Function
12.4. Factors Controlling ABCG2 Expression
12.5. Substrates of ABCG2
12.6. Inhibitors of ABCG2
12.7. Tissue Localization of ABCG2
12.8. Function Predicted From Tissue Distribution
12.8.1. Stem Cells
12.8.2. Placenta
12.8.3. Mammary Gland
12.8.4. Testis
12.8.5. Blood-Brain Barrier
12.8.6. Liver and Gastrointestinal Tract
12.9. Genetic Polymorphisms
12.10. ABCG2 Expression in Cancer and Its Role in Drug Resistance
12.11. Cancer Stem Cells
12.12. Conclusions
References
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