MULTIDRUG RESISTANCE PROTEINS OF THE ABCC SUBFAMILY - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 286

TABLE 11.3. Immunodetection of ABCC/MRP Efflux Pumps in Clinical Specimens of
Selected Human Solid Tumors
Type of Tumor ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 ABCC6 Ref.

2/11 a
80/100

Breast carcinoma 215

216
191 25/49

Colorectal
carcinoma

4/13
30/30
56/139

215
217
218
191 39/50

Esophagus
squamous cell
carcinoma

12/12
54/86

215
218

Gastric carcinoma 35/103

11/20

218
219
191

8/13

Gastrointestinal
stromal tumors

9/26
13/21

220
221

Glioma 16/23

12/20
12/17
14/15
0/50
13/25

222
223
224
225
226
227

0/46 0/46

7/25

36/61
11/25

35/58 0/46

Hepatocellular
carcinoma

3/6 33/38 9/9 228

Non-small cell
lung cancer

28/59
23/27
5/27
13/109

229
215
230
178
191 14/32

Melanoma 0/10

13/21

215
231

Ovarian carcinoma 9/15

13/58
17/21
39/60
51/115

215
232
233
234
191
235

16/17
19/115

Renal carcinoma 2/6 215

189
191

18/19
9/22

Retinoblastoma 8/16 5/16 0/16 236

Soft tissue sarcoma 0/14

37/86

215
237 27/86 31/86

Testicular
carcinoma

56/56 238

Thyroid carcinoma 9/12 239
a The first number is that of samples positive for the respective ABCC/MRP protein; the second number is
the total number of samples investigated.