ORGANIC CATION TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 11

ORGANIC CATION TRANSPORTERS

THOMAS J. URBAN AND KATHLEEN M. GIACOMINI
University of California San Francisco, San Francisco, California

2.1. Introduction
2.2. Structural-Functional Characteristics and Transport Mechanism
2.3. Substrate Selectivity
2.4. Tissue Distribution
2.5. Regulation of OCT Expression and Activity
2.5.1. OCT1
2.5.2. OCT2
2.5.3. OCT3
2.6. Animal Models
2.6.1. Oct1 Knockout Mice
2.6.2. Oct2 Knockout Mice
2.6.3. Oct1/Oct2 Knockout Mice
2.6.4. Oct3 Knockout Mice
2.7. Genetic Variation
2.7.1. OCT1
2.7.2. OCT2
2.7.3. OCT3
2.8. Conclusions
References