MULTIDRUG RESISTANCE PROTEINS OF THE ABCC SUBFAMILY - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 266

TABLE 11.1. Nomenclature and Properties of the Human ABCC Genes and ABCC Proteins
Alternative Gene Accession

Chromosomal Gene Size Number of Protein Accession Amino Amino Acid

Number a Localization a (bases) a Exons a Number b Acids b Identity b Symbol Name Topology

ABCC1 MRP1 NM 004996 16p13.1 192,839 31, ref. 18 NP 004987 1531 100 MSD0-MSD1-NBD1-

MSD2-NBD2

ABCC2 MRP2 NM 000392 10q24 69,460 32, refs.

19,20

NP 000383 1545 50 MSD0-MSD1-NBD1-

MSD2-NBD2

ABCC3 MRP3 NM 003786 17q22 56,835 31, ref. 21 NP 003777 1527 58 MSD0-MSD1-NBD1-

MSD2-NBD2

ABCC4 MRP4 NM 005845 13q32 281,593 31, refs.

21,22

NP 005836 1325 41 MSD1-NBD1-MSD2-

NBD2

ABCC5 MRP5 NM 005688 3q27 98,005 30, ref. 23 NP 005679 1437 38 MSD1-NBD1-MSD2-

NBD2

ABCC6 MRP6 NM 001171 16p13.1 73,324 31, ref. 24 NP 001162 1503 46 MSD0-MSD1-NBD1-

MSD2-NBD2

ABCC10 MRP7 NM 033450 6p21.1 22,871 22, ref. 23 NP 258261 1464 35 MSD0-MSD1-NBD1-

MSD2-NBD2

ABCC11 MRP8 NM 033151 16q12.1 80,483 29, ref. 25

30, ref. 26
31, ref. 27

NP 149163 1382 33 MSD1-NBD1-MSD2-

NBD2

ABCC12 MRP9 NM 033226 16q12.1 63,797 29, refs.

25,26

NP 150229 1359 36 MSD1-NBD1-MSD2-

NBD2

CFTR ABCC7 NM 000492 7q31.2 188,698 27, ref. 28 NP 000483 1480 30 MSD1-NBD1-MSD2-

NBD2

ABCC8 SUR1 NM 000352 11p15.1 84,016 39, ref. 29 NP 000343 1581 36 MSD0-MSD1-NBD1-

MSD2-NBD2

ABCC9 SUR2A NM 005691 12p12.1 140,189 38, ref. 29 NP 005682 1549 35 MSD0-MSD1-NBD1-

MSD2-NBD2

SUR2B NM 020297 12p12.1 140,189 38, ref. 29 NP 064693 1549 36