MULTIDRUG RESISTANCE PROTEINS OF THE ABCC SUBFAMILY - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 263

11

MULTIDRUG RESISTANCE PROTEINS
OF THE ABCC SUBFAMILY

ANNE T. NIES, MARIA RIUS, AND DIETRICH KEPPLER
German Cancer Research Center, Heidelberg, Germany

11.1. Introduction
11.2. Discovery of the ABCC/MRP Efflux Pumps and Genomic Organization of the
ABCC Genes
11.3. Molecular Characterization
11.3.1. Domain Structure of the ABCC Proteins
11.3.2. Amino Acid Sequence Identities of Human ABCC/MRP Paralogs
11.3.3. ABCC/MRP Orthologs in Other Species and Phylogenetic Analysis
11.4. Substrate Specificity and Multidrug Resistance Profiles of Human ABCCs/MRPs
11.4.1. ABCC1
11.4.2. ABCC2
11.4.3. ABCC3
11.4.4. ABCC4
11.4.5. ABCC5
11.4.6. ABCC6
11.4.7. ABCC10
11.4.8. ABCC11 and ABCC12
11.5. Localization of ABCC/MRP Efflux Pumps in Normal Human Tissues and
in Human Cancers
11.5.1. ABCC1
11.5.2. ABCC2
11.5.3. ABCC3
11.5.4. ABCC4
11.5.5. ABCC5