MULTIDRUG RESISTANCE PROTEIN: P-GLYCOPROTEIN - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 251

38. Rosenberg MF, Callaghan R, Ford RC, Higgins CF. 1997. Structure of the multidrug
resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and
image analysis. J Biol Chem 272:10685-10694.
39. Qu Q, Sharom FJ. 2001. FRET analysis indicates that the two ATPase active sites of
the P-glycoprotein multidrug transporter are closely associated. Biochemistry 40:1413-
1422.
40. Urbatsch IL, Gimi K, Wilke-Mounts S, Lerner-Marmarosh N, Rousseau ME, Gros P,
Senior AE. 2001. Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-
linking between the two nucleotide-binding sites in human P-glycoprotein. J Biol Chem
276:26980-26987.
41. Loo TW, Bartlett MC, Clarke DM. 2002. The “LSGGQ” motif in each nucleotide-binding
domain of human P-glycoprotein is adjacent to the opposing Walker A sequence. J Biol
Chem 277:41303-41306.
42. Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R,
Schmidlin A, Wooding C, Linton KJ, Higgins CF. 2001. Repacking of the transmem-
brane domains of P-glycoprotein during the transport ATPase cycle. EMBO J 20:5615-
5625.
43. Rosenberg MF, Kamis AB, Callaghan R, Higgins CF, Ford RC. 2003. Three-dimensional
structures of the mammalian multidrug resistance P-glycoprotein demonstrate major con-
formational changes in the transmembrane domains upon nucleotide binding. J Biol Chem
278:8294-8299.
44. Lee JY, Urbatsch IL, Senior AE, Wilkens S. 2002. Projection structure of P-glycoprotein
by electron microscopy: evidence for a closed conformation of the nucleotide binding
domains. J Biol Chem 277:40125-40131.
45. Rosenberg MF, Callaghan R, Modok S, Higgins CF, Ford RC. 2005. Three-dimensional
structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configura-
tion in the nucleotide-bound state. J Biol Chem 280:2857-2862.
46. Loo TW, Clarke DM. 2000. The packing of the transmembrane segments of human
multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis. J Biol
Chem 275:5253-5256.
47. Loo TW, Bartlett MC, Clarke DM. 2004. Val 133 and Cys 137 in transmembrane segment 2
are close to Arg 935 and Gly 939 in transmembrane segment 11 of human P-glycoprotein. J
Biol Chem 279:18232-18238.
48. Loo TW, Bartlett MC, Clarke DM. 2004. Disulfide cross-linking analysis shows that
transmembrane segments 5 and 8 of human P-glycoprotein are close together on the
cytoplasmic side of the membrane. J Biol Chem 279:7692-7697.
49. al-Shawi MK, Senior AE. 1993. Characterization of the adenosine triphosphatase activity
of Chinese hamster P-glycoprotein. J Biol Chem 268:4197-4206.
50. Doige CA, Yu X, Sharom FJ. 1992. ATPase activity of partially purified P-glycoprotein
from multidrug-resistant Chinese hamster ovary cells. Biochim Biophys Acta 1109:149-
160.
51. Safa AR, Glover CJ, Meyers MB, Biedler JL, Felsted RL. 1986. Vinblastine photoaffin-
ity labeling of a high molecular weight surface membrane glycoprotein specific for
multidrug-resistant cells. J Biol Chem 261:6137-6140.
52. Cornwell MM, Tsuruo T, Gottesman MM, Pastan I. 1987. ATP-binding properties of
P-glycoprotein from multidrug-resistant KB cells. FASEB J 1:51-54.