Biomedical Engineering Reference
In-Depth Information
10
MULTIDRUG RESISTANCE PROTEIN:
P-GLYCOPROTEIN
FRANCES J. SHAROM
University of Guelph, Guelph, Ontario, Canada
10.1. P-Glycoprotein Gene Family
10.2. Tissue Distribution of P-Glycoprotein
10.3. Role of P-Glycoprotein in Human Physiology
10.4. P-Glycoprotein Substrates and Modulators
10.5. P-Glycoprotein Structure
10.6. Subcellular Systems for Studying P-Glycoprotein
10.7. ATP Binding and Hydrolysis by P-Glycoprotein
10.8. Drug Binding to P-Glycoprotein
10.9. P-Glycoprotein-Mediated Drug Transport
10.10. Substrate Specificity of P-Glycoprotein and Nature of the Drug-Binding Site
10.11. P-Glycoprotein as a Hydrophobic Vacuum Cleaner or Drug Flippase
10.12. Role of the Lipid Bilayer in P-Glycoprotein Function
10.13. Mechanism of Action of P-Glycoprotein
10.14. Role of P-Glycoprotein in Drug Therapy
10.15. Modulation of P-Glycoprotein in Cancer Treatment
10.16. Regulation of P-Glycoprotein Expression
10.17. P-Glycoprotein Gene Polymorphisms and Their Implications in Drug Therapy and
Disease
10.18. Conclusions
References
Search WWH ::
Custom Search