OVERVIEW OF DRUG TRANSPORTER FAMILIES - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 5

TABLE 1.1. Classification of Drug Transporters
Family

Gene Human

Transporter Family Member Name Chromosome Locus Ref. a

Organic cation
transporter (OCT)

hOCT1 SLC22A1 6q26 1

hOCT2 SLC22A2 6q26 1

hOCT3 SLC22A3 6q26-q27 2

Organic cation/carnitine
transporter (OCTN)

OCTN1 SLC22A4 5q31.1 3

OCTN2 SLC22A5 5q31 4

OCTN3 SLC22A21 5q31 5

CT2 SLC22A16 6q22.1 6

Organic anion
transporter (OAT)

OAT1 SLC22A6 11q13.1-q13.2 7

OAT2 SLC22A7 6p21.2-p21.1 8

OAT3 SLC22A8 11q11.7 9

OAT4 SLC22A11 11q13.1 10

OAT5 SLC22A10 11q12.3 11

OAT6 SLC22A20 unknown —

URAT1 SLC22A12 11q13.1 10

Organic anion transporter
polypeptides (OATPs)

OATP1C1 SLCO1C1 12p12.2 12

OATP1B1 SLCO1B1 12p12.2 13

OATP1A2 SLCO1A2 12p12 12

OATP1B3 SLCO1B3 12p12 14

OATP2A1 SLCO2A1 3q21 15

OATP2B1 SLCO2B1 11q13 16

OATP3A1 SLCO3A1 15q26 17

OATP4A1 SLCO4A1 20q13.33 17

OATP4C1 SLCO4C1 5q21.2 18

OATP5A1 SLCO5A1 8q13.3 19

OATP6A1 SLCO6A1 5q21.1 20

Peptide transporter
(PEPT)

PEPT1 SLC15A1 13q33-q34 21

PEPT2 SLC15A2 3q21.1 22

PHT1 SLC15A4 12q24.32 23

PHT2 SLC15A3 11q12.2 24

Monocarboxylate
transporters (MCTs,
sMCTs)

MCT1 SLC16A1 1p12 25

MCT2 SLC16A7 12q13 26

MCT3 SLC16A8 22q12.3-q13.2 27

MCT4 SLC16A3 17q25 28

SMCT1 SLC5A8 12q23 29

SMCT2 SLC5A12 11p14 24

( Continued )