BILE ACID TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 219

regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest , 102 , 1016-
1023.
71. Makishima, M., Lu, T.T., Xie, W., Whitfield, G.K., Domoto, H., Evans, R.M., Haussler,
M.R. and Mangelsdorf, D.J. (2002) Vitamin D receptor as an intestinal bile acid sensor.
Science , 296 , 1313-1316.
72. Kassam, A., Miao, B., Young, P.R. and Mukherjee, R. (2003) Retinoid X receptor
(RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to ab-
sence of coactivator recruitment and decreased DNA binding. J Biol Chem , 278 , 10028-
10032.
73. Tzameli, I., Chua, S.S., Cheskis, B. and Moore, D.D. (2003) Complex effects of rexinoids
on ligand dependent activation or inhibition of the xenobiotic receptor, CAR. Nucl Recept ,
1 ,2.
74. Claudel, T., Sturm, E., Duez, H., Torra, I.P., Sirvent, A., Kosykh, V., Fruchart, J.C.,
Dallongeville, J., Hum, D.W., Kuipers, F. and Staels, B. (2002) Bile acid-activated nuclear
receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response
element. J Clin Invest , 109 , 961-971.
75. Claudel, T., Inoue, Y., Barbier, O., Duran-Sandoval, D., Kosykh, V., Fruchart, J., Fruchart,
J.C., Gonzalez, F.J. and Staels, B. (2003) Farnesoid X receptor agonists suppress hepatic
apolipoprotein CIII expression. Gastroenterology , 125 , 544-555.
76. Eloranta, J.J. and Kullak-Ublick, G.A. (2005) Coordinate transcriptional regulation of
bile acid homeostasis and drug metabolism. Arch Biochem Biophys , 433 , 397-412.
77. Borgius, L.J., Steffensen, K.R., Gustafsson, J.A. and Treuter, E. (2002) Glucocorticoid
signaling is perturbed by the atypical orphan receptor and corepressor SHP. J Biol Chem ,
277 , 49761-49766.
78. Kim, J.Y., Kim, H.J., Kim, K.T., Park, Y.Y., Seong, H.A., Park, K.C., Lee, I.K., Ha, H.,
Shong, M., Park, S.C. and Choi, H.S. (2004) Orphan nuclear receptor small heterodimer
partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its
DNA binding. Mol Endocrinol , 18 , 2880-2894.
79. Kemper, J.K., Kim, H., Miao, J., Bhalla, S. and Bae, Y. (2004) Role of an mSin3A-Swi/Snf
chromatin remodeling complex in the feedback repression of bile acid biosynthesis by
SHP. Mol Cell Biol , 24 , 7707-7719.
80. Wang, L., Lee, Y.K., Bundman, D., Han, Y., Thevananther, S., Kim, C.S., Chua, S.S., Wei,
P., Heyman, R.A., Karin, M. and Moore, D.D. (2002) Redundant pathways for negative
feedback regulation of bile acid production. Dev Cell , 2 , 721-731.
81. Kerr, T.A., Saeki, S., Schneider, M., Schaefer, K., Berdy, S., Redder, T., Shan, B., Russell,
D.W. and Schwarz, M. (2002) Loss of nuclear receptor SHP impairs but does not eliminate
negative feedback regulation of bile acid synthesis. Dev Cell , 2 , 713-720.
82. Gupta, S., Natarajan, R., Payne, S.G., Studer, E.J., Spiegel, S., Dent, P. and Hylemon, P.B.
(2004) Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor
activation in primary hepatocytes: role of acidic sphingomyelinase-mediated ceramide
generation in FAS receptor activation. J Biol Chem , 279 , 5821-5828.
83. Qiao, L., Han, S.I., Fang, Y., Park, J.S., Gupta, S., Gilfor, D., Amorino, G., Valerie,
K., Sealy, L., Engelhardt, J.F. et al. (2003) Bile acid regulation of C/EBPbeta, CREB,
and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal
kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol , 23 ,
3052-3066.