Biomedical Engineering Reference
In-Depth Information
BILE ACID TRANSPORTERS
JYRKI J. ELORANTA AND GERD A. KULLAK-UBLICK
University Hospital Zurich, Division of Clinical Pharmacology and Toxicology,
Zurich, Switzerland
9.1. Overview of the Enterohepatic Circulation of Bile Acids
9.2. Chief Transporters in the Enterohepatic Circulation of Bile Acids
9.3. Enterohepatic Bile Acid Transporters in Liver Disease
9.4. Control of Bile Acid Transport and Metabolism
9.5. Nuclear Receptors as Transcriptional Regulators of Bile Acid Homeostasis
9.5.1. FXR: The Master Regulator of Bile Acid Transport and Metabolism
9.5.2. Role of PXR and VDR as Bile Acid Sensors
9.5.3. Bile Acid-Induced Transcriptional Repressor SHP
9.6. FXR-Dependent Mechanisms That Regulate Human Bile Acid Transporter Genes
9.6.1. Positive Feedforward Control of Bile Acid Efflux Systems by Bile Acids
9.6.2. Negative Feedback Control of Bile Acid Uptake Systems by Bile Acids
9.7. Crosstalk Between the Transcriptional Control of Bile Acid and Drug Transporters
9.8. Conclusions
References
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