NUCLEOSIDE TRANSPORTERS: CNTs AND ENTs - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 197

nucleoside transporters 1 and 2 produced in Saccharomyces cerevisiae . Nucleosides Nu-
cleotides Nucleic Acids 23(1-2):361-373.
90. Sundaram M, Yao SY, Ingram JC, Berry ZA, Abidi F, Cass CE, Baldwin SA, Young JD.
2001. Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive
nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-
cancer drugs. J Biol Chem 276(48):45270-45275.
91. Vickers MF, Mani RS, Sundaram M, Hogue DL, Young JD, Baldwin SA, Cass CE. 1999.
Functional production and reconstitution of the human equilibrative nucleoside trans-
porter (hENT1) in Saccharomyces cerevisiae . Interaction of inhibitors of nucleoside trans-
port with recombinant hENT1 and a glycosylation-defective derivative (hENT1/N48Q).
Biochem J 339(Pt 1):21-32.
92. Ward JL, Leung GP, Toan SV, Tse CM. 2003. Functional analysis of site-directed gly-
cosylation mutants of the human equilibrative nucleoside transporter-2. Arch Biochem
Biophys 411(1):19-26.
93. Sundaram M, Yao SY, Ng AM, Cass CE, Baldwin SA, Young JD. 2001. Equilibra-
tive nucleoside transporters: mapping regions of interaction for the substrate analogue
nitrobenzylthioinosine (NBMPR) using rat chimeric proteins. Biochemistry 40(27):
8146-8151.
94. Yao SY, Sundaram M, Chomey EG, Cass CE, Baldwin SA, Young JD. 2001. Iden-
tification of Cys140 in helix 4 as an exofacial cysteine residue within the substrate-
translocation channel of rat equilibrative nitrobenzylthioinosine (NBMPR)-insensitive
nucleoside transporter rENT2. Biochem J 353(Pt 2):387-393.
95. Visser F, Vickers MF, Ng AM, Baldwin SA, Young JD, Cass CE. 2002. Mutation of
residue 33 of human equilibrative nucleoside transporters 1 and 2 alters sensitivity to
inhibition of transport by dilazep and dipyridamole. J Biol Chem 277(1):395-401.
96. Visser F, Zhang J, Raborn RT, Baldwin SA, Young JD, Cass CE. 2005. Residue 33 of
human equilibrative nucleoside transporter 2 is a functionally important component of
both the dipyridamole and nucleoside binding sites. Mol Pharmacol 67(4):1291-1298.
97. SenGupta DJ, Lum PY, Lai Y, Shubochkina E, Bakken AH, Schneider G, Unadkat JD.
2002. A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1,
alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine. Biochemistry
41(5):1512-1519.
98. Endres CJ, Unadkat JD. 2005. Residues Met89 and Ser160 in the human equili-
brative nucleoside transporter 1 affect its affinity for adenosine, guanosine, S 6-(4-
nitrobenzyl)mercaptopurine riboside, and dipyridamole. Mol Pharmacol 67(3):837-844.
99. Endres CJ, SenGupta DJ, Unadkat JD. 2004. Mutation of leucine-92 selectively reduces
the apparent affinity of inosine, guanosine, NBMPR [ S 6-(4-nitrobenzyl)mercaptopurine
riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1. Biochem
J 380(Pt 1):131-137.
100. Visser F, Baldwin SA, Isaac RE, Young JD, Cass CE. 2005. Identification and muta-
tional analysis of amino acid residues involved in dipyridamole interactions with hu-
man and Caenorhabditis elegans equilibrative nucleoside transporters. J Biol Chem
280(12):11025-11034.
101. Cabrita MA, Baldwin SA, Young JD, Cass CE. 2002. Molecular biology and regulation of
nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes. Biochem
Cell Biol 80(5):623-638.