OVERVIEW OF DRUG TRANSPORTER FAMILIES - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 1

OVERVIEW OF DRUG
TRANSPORTER FAMILIES

GUOFENG YOU
Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey,
Piscataway, New Jersey
MARILYN E. MORRIS
School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State
University of New York, Amherst, New York

1.1. What Are Drug Transporters?
1.2. Structure and Model of Drug Transporters
1.3. Transport Mechanisms
1.4. Polarized Expression of Drug Transporters in Barrier Epithelium
1.5. Classification of Drug Transporters
1.5.1. Definition of Efflux and Influx Transporters
1.5.2. Definition of Absorptive and Secretory Transporters
1.5.3. Relationship Between Influx-Efflux and Absorptive-Secretory Transporters
1.5.4. ABC and SLC Transporters
References

1.1. WHAT ARE DRUG TRANSPORTERS?

Transporters are membrane proteins whose primary function is to facilitate the flux of
molecules into and out of cells. Drug transporters did not evolve to transport specific