NUCLEOSIDE TRANSPORTERS: CNTs AND ENTs - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 171

NUCLEOSIDE TRANSPORTERS:
CNTs AND ENTs

LI XIA, MINGYAN ZHOU, AND JOANNE WANG
University of Washington, Seattle, Washington

8.1. Introduction
8.2. Concentrative Nucleoside Transporters (SLC28)
8.2.1. Family Members
8.2.2. Transport Mechanisms
8.3. Equilibrative Nucleoside Transporters (SLC29)
8.3.1. Family Members
8.3.2. Transport Mechanisms
8.4. Regulation of Nucleoside Transporters
8.5. Physiological Roles of Nucleoside Transporters
8.6. Clinical Significance of Nucleoside Transporters
8.7. Polymorphisms of Nucleoside Transporters
8.8. Conclusions
References

8.1. INTRODUCTION

Endogenous nucleosides (Figure 8.1) are important precursors of nucleic acid syn-
thesis, a process fundamental to the growth and metabolism in all living systems. The
purine nucleoside adenosine is also a key signaling molecule that exerts profound