MAMMALIAN OLIGOPEPTIDE TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 115

TABLE 6.2. Summary of the Molecular and Functional Characteristics of Established Human Oligopeptides Transporters and
Splice Variants

Transporter PepT1 PepT1-RF Pg-PepT1 PepT2 PHT1 PHT2 PT-1

Family POT PepT1-splice

variant

PepT1-splice
variant

POT POT POT Cadherin

Protein length 708 a.a. 208 a.a. 150 a.a. 729 a.a. 572 a.a. 581 a.a. 832 a.a

Transmembrane
domains

12 6 3 12 12 12 10

Established
substrates

Di- and
tripeptides,
peptide-
based
agents

N.A.: alters pH
sensitivity of
PepT1

N.A.: forms
heterodimer
with hPepT1 to
decrease
Gly-Sar uptake

Di- and
tripeptides,
peptide-
based
agents

Histidine, di-
and
tripeptides,
valacyclovir

Histidine,
carnosine,
di- and
tripeptides

Di- and
tripeptides,
peptide-
based
agents