ORGANIC ANION–TRANSPORTING POLYPEPTIDES - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 86

TABLE 5.3. ( Continued )
Transporter Substrates Nonsubstrates Inhibitors

OATP2A1 PGE 118

2

, PGE 118
1

, PGF 118
2

, PGD 118
2

, TXB 118
2

Iloprost 118 Furosemide 118 , TGBz T34 148

OATP2B1 E 1 S 116 , benzylpenicillin 116 , PGE 11 2 , BSP 27 ,

DHEAS 27 , pravastatin 22 , fluvastatin,
rosuvastatin 39 , glybenclamide 149 ,
fexofenadine 17

E 2 G 116 , GCA 27 , TCA 27 , oubain 27 ,
digoxin 27 ,LTC 4 27 , PGE 2 27 ,
T 3 27 ,T 4 27 , deltophin 27 ,
DPDPE 27 , BQ-123 27

Benzoate 22 , nicotinate 22 , phthalate 22 ,PAH 150 ,
indomethacin 150 , TCA 150 , cimetidine 150 ,
salicylate 150 , valproate 150 , rifamycin SV 142 ,
grapefruit juice 149 , orange juice 149 , naringin 149 ,
naringenin 149 , quercetin 149 , bergamottin 149 ,
dihydroxybergamottin 149 , tangeritin 149 ,
nobelitin 149 , bilberry 151 , echinacea 151 , green
tea 151 , banaba 151 , grape seed 151 , ginkgo 151 ,
soybean 151 , mulberry 151 , black cohosh 151 , and
Siberian ginseng 151

, PGE 116 , 121
2

PGE 121
1

, PGF 121
2

, benzylpenicillin 116 , PGD 12 2 , TBX 121 , iloprost 121 ,

MTX 121 , TCA 116 ,E 2 G 116

PGD 121
2

,PAH 121

OATP3A1

E 1 S 116

T 152
3

,T 15 4 , TCA 152 ,E 2 G 116 , benzylpenicillin 116 ,
PGE 2 116 ,E 1 S 116

PA H 152 , PGE 152
1

, PGD 152
2

BSP 152

OATP4A1 ,

152

PGF2

Digoxin 147 , oubain 147 ,T 3 147 ,T 147
4

, MTX 147 , TCA 147 ,E 2 G 147 , PGE 2 147 ,PAH 147 ,

pravastatin 147 , temocaprilat 147 ,
ASA 147 , salicylate 147 , urate 147 ,
acyclovir 147 , ochratoxin 147 ,
benzylpenicillin 147 , cGMP 147 ,
TEA 147

Digitoxin 147 , Digitoxigenin 147 OATP4C1

cAMP 147

OATP5A1 ? ? ?

-estradiol, testosterone) 106
a BSP, bromosulfophthalein; CCK-8, cholecystokinin octapeptide; CyA, cyclosporine A; DADLE, [D-Ala(2), D-Leu(5)]-enkephalin; DPDPE, [D-penicillamine 2 , 5 ]
enkephalin; E 1 S, estrone sulfate; E 2 G, estradiol 17 -glucuronide; DHEAS, dehydroepiandrostane sulfate; GCA, glycocholate; GUDC, glycoursodeoxycholate; LTC 4 ,
leukotriene C 4 ; MTX, methotrexate; NMQ, N -methylquinidine; PAH, p -aminohipurrate; PGD 2 , prostaglandin D 2 ; PGE 1 , prostaglandin E 1 ; PGE 2 , prostaglandin E 2 ;

rGST1 (T 3 ,T 4 , DHEAS, TCA) 106 OATP6A1 rGST1 (