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By scaling the mother functions and convoluting them with the original image, a
set of spatial-frequency spaces are constructed as Eq. ( 5 ).
F l ð
x
;
s
Þ ¼
H l ð
sx
Þ
I
ð
x
Þ
ð
5
Þ
where s and l denote the scaling factor and index of mother functions, respectively.
Finally, for any voxel x 0 2<
3 , its feature vector
is obtained by sampling
these spatial-frequency spaces in the neighborhood of x 0 (Eq. 6 ). It provides cross-
scale appearance descriptions of voxel x 0 .
x 0 Þ
[
l¼1 ... L f F l ð x i ; s j Þj x i 2 N ð x 0 Þ; s min \ s j \ s max g
x 0 Þ ¼
ð
6
Þ
Compared to standard Haar wavelet, the mother functions we employed are not
orthogonal. However, they provide more comprehensive image features to char-
acterize different anatomy primitives. For example, as shown in Fig. 3 , mother
function (a) potentially works as a smoothing
filter, which is able to extract regional
features. Mother functions (b) and (c) can generate horizontal or vertical
responses, which are robust to local noises. More complicated mother function like
(d) is able to detect
edgeness
patterns, which might be useful to distinguish some
anatomy primitives. In addition, our features can be quickly calculated through
integral image [ 21 ]. It paves the way to an ef
L-shape
cient anatomy detection system.
All elementary features are then fed into a cascade classi
cation framework [ 22 ]
as shown in Fig. 4 . The cascade framework is designed to address the highly
unbalanced positive and negative samples. In fact, since only voxels around ver-
tebrae centers or intervertebral discs are positives, the ratio of positives to negatives
is often less than 1:10 5 . In the training stage, all positives but a small proportion of
Fig. 3 Some examples of haar-based mother functions
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