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Fig. 17 Cumulative probability plots for changes in a syndesmophyte computed volume,
b modified stoke AS spine score (mSASSS)
where the ridgelines (same vertebral body at different times) should be fairly
similar, averaging can for instance be done in the direction normal to the curves.
Starting from the baseline curve, for each curve point, a local normal direction can
be estimated. On the year 1 or 2 curve, the curve point most aligned with that
normal direction can be determined and averaged with the curve point on the
baseline curve.
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