Biomedical Engineering Reference
In-Depth Information
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CHAPTER 3
Probing Biointerfaces:
Electrokinetics
RALF ZIMMERMANN,*
a
J
´
R
ˆ
ME F. L. DUVAL
b,c
AND
CARSTEN WERNER
a,d
a
Leibniz Institute of Polymer Research Dresden, Max Bergmann Center
of Biomaterials Dresden, Hohe Strasse 6, 01069 Dresden, Germany;
b
Universit´ de Lorraine, Laboratoire Interdisciplinaire des
Environnements Continentaux (LIEC), UMR 7360, Vandoeuvre-l`s-Nancy
F-54501, France;
c
CNRS, LIEC, UMR 7360, Vandoeuvre-l`s-Nancy, F-54501,
France;
d
Technische Universit¨t Dresden, Center for Regenerative
Therapies Dresden, Tatzberg 47, 01307 Dresden, Germany
*Email: zimmermn@ipfdd.de
.
3.1 Introduction
The contact of biomaterials with aqueous environments very often involves
the formation of bulk and interfacial charges.
1-5
In turn, the structure and
function of the materials and their interfaces are largely governed by elec-
trostatic interactions that depend on the degree of ionization of functional
groups and by ion-specific interactions within the molecular architecture of
the material.
6-9
Furthermore, electrostatic interactions were found to be
relevant for a number of interfacial processes such as wetting,
10
protein
binding to extracellular matrix,
11-13
proteins and nucleic acid stability in the
vicinity of/at biomaterial interfaces,
14
interaction kinetics between these
components and biosurfaces
14,15
and membrane permeability to proteins
and drugs.
16,17
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