Biomedical Engineering Reference
In-Depth Information
d
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r
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Figure 12.12 Plots of the number, projected area, and the aspect ratio of adhering
fibroblasts with the relative amount of the cell-binding motifs on the
polymer surfaces as well as with the Mf values. The aspect ratio was
calculated by dividing the short axis of the best-fit ellipse of adhering
fibroblast with the long axis. The best-fit ellipse was modeled by using
Image-J.
Reproduced/adapted from ref. 53 with permission from Elsevier.
reason why this relationship was found is still unclear. However, the fol-
lowing hypothesis was postulated: 'Because cell surfaces are dynamically
changing and reordering their surfaces, the materials surfaces can conduct
dynamic ECM adsorption are considered to induce the specific morphology
of adhering cells'.
Acknowledgements
The authors are grateful for the many collaborations, discussions and ex-
perimental support for the various research studies cited here. Special
thanks are due to Prof. Tetsuji Yamaoka, Prof. Kazuhiko Ishihara, Dr Sachiro
Kakinoki, Dr Yuuki Inoue and Dr Atsushi Tamura.
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