Biomedical Engineering Reference
In-Depth Information
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CHAPTER 12
Design of Mobile
Supramolecular Biointerfaces
for Regulation of Biological
Responses
JI-HUN SEO
a,b
AND NOBUHIKO YUI*
a,b
a
JST-CREST, Chiyoda, Tokyo 102-0076, Japan;
b
Institute of Biomaterials
and Bioengineering, Tokyo Medical and Dental University, Chiyoda,
Tokyo 102-0062, Japan
*Email: yui.org@tmd.ac.jp
.
12.1 Introduction
As a result of the development of materials engineering, various types of
artificial materials are now being used in biological environments for the
purpose of repairing organs, regenerating tissues, or slowing down of dis-
eases.
1
The artificial materials that directly contact with the living body to
replace or augment the faulted places are called 'biomaterials', and under-
standing interfacial phenomenon on the biomaterials surfaces in the bio-
logical environments is crucial
to the design of effective and safe
biomaterials.
When artificial materials are placed in biological environments large
amounts of protein molecules interact immediately with biomaterials sur-
faces.
2
Because around 80% of dried body fluid is composed of protein
molecules, protein material surface interactions are responsible for the most
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