Biomedical Engineering Reference
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Figure 9.6
(a) PCL-TCP-collagen scaffold was implanted into a rat calvarial defect
site. (b) Representative mCT analysis shows full closure in BMP-2 treated
sites at 15 weeks. (c) Bone specific staining of histological sections (left to
right); Von Kossa, Goldner's trichrome and Masson's trichrome. Exten-
sive bone healing is shown in scaffolds treated with BMP-2.
Adapted from Sawyer et al.
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fracture and pseudoarthrosis, which were observed in the control group
(autograft bone), were absent at both time points in the experimental
rhBMP-2 loaded PCL-TCP-collagen scaffold implants.
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This short-term
study demonstrated that a porous PCL-TCP-collagen scaffold designed for
bone healing at a load-bearing site, when supplemented with low doses of
rhBMP-2, can promote bone regeneration and bone fusion in a large animal
model of anterior lumbar interbody fusion.
In a more recent study, Kang et al.
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compared loading PCL scaffolds
with cells and BMP-2. PCL scaffolds were loaded with BMSCs and/or BMP-2
using fibrin glue as a carrier matrix. These scaffolds were implanted into
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