Biology Reference
In-Depth Information
1.4 Some Major Steps in the Development
of Tetrapyrrole-Dependent Photobiotechnologies
In this historical section, emphasis is placed on the development of tetrapyrrole-
dependent photobiotechnologies.
1.4.1 Lipson et al., 1961
In 1961, Lipson et al. synthesized hematoporphyrin derivative (HPD), the first practi-
cal photodynamic therapy drug used in the treatment of cancer (Lipson et al. 1961 ).
1.4.2 Rebeiz, et al., 1984
In 1984, Rebeiz et al., described the concept and phenomenology of tetrapyrrole-
dependent photodynamic herbicides (Rebeiz et al. 1984b ).
1.4.3 Pottier et al., 1986
In 1986, Pottier et al., used delta-aminolevulinic acid (ALA)-induced Proto in the
treatment of cancerous tumors (Pottier et al. 1986 ).
1.4.4 Rebeiz et al., 1988
In 1988, Rebeiz et al. described the concept and phenomenology of tetrapyrrole-
dependent photodynamic insecticides (Rebeiz et al. 1988a ).
1.4.5 Matringe et al., 1989
1989: Matringe et al., demonstrated the inhibition of protoporphyrinogen IX
oxidase by diphenyl ether herbicides.
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