Porphyric Insecticides - Chlorophyll Biosynthesis and Technological Applications - page 430

effects were positively correlated with Proto accumulation and the presence of both
ALA and modulator were required for activity (Table 18.14 ,#19,20).Highly
substituted pyrroles such as tert-butyl 4-acetyl-3,5-dimethyl-2-pyrrole-carboxylate
exhibited low insecticidal activity (Fig. 18.7 ; Table 18.14 , # 17, 18). However
tetrahydroindoles with an isolated keto group at position 4, as in 3-ethyl-2-methyl-
4,5,6,7-tetrahydroindol-4-one, were active (Fig. 18.7 ;Table 18.14 ,#19,20).Removal
of the ketone group resulted in complete loss of activity as in 4,5,6,7-tetrahydroindole
(Fig. 18.7 ; Table 18.14 , # 15, 16). This was accompanied by a substantial decrease in
electron density (from 1.03 to 0.52 kcal/mol) of the unoccupied molecular orbitals,
and a significant decrease (from 132.3 to 61.8 A 3) in volumes of the positive charge
binding electrostatic field.
18.7 Epilogue
It is hoped that based on the reported investigations it will be possible to develop
safe formulation for the control of household pests. It will be more difficult to
develop formulations for the control of insects on living plants as the ALA and
modulators so far described appear to destroy the plant as well as the insect.
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